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REDEFINE 2 (Phase 3a, NEJM 2025) Davies et al., n=1,206, 68 weeks, T2D + BMI 27

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Elevated levels have also been detected in patients with lupus, rosacea, and some forms of inflammatory bowel disease

Synergy, Delivery, and Open Questions Given the distributed control of follicular biology, combination strategies may be necessary to achieve durable remodeling: for example, pairing a vascular/matrix modulator (e.g., TB-500) with agents that stabilize anagen signaling (e.g., Wnt pathway enhancers) or with protocols that increase local growth factor availability

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