The level of cysteine, a substrate for glutathione synthesis, remained beyond the limit of quantification for the method used (Table 1), but a statistically significant increase in the cystine level was observed in one case (Table 1) after the direct administration of 1% DMSO into the serum-free medium (the WT cells)
It is still not known why an oxidizing balance of glutathione is required in the ER or how this balance is maintained
[DOI] [PubMed] [Google Scholar] [80].Ohta H, Sunden Y, Yokoyama N, Osuga T, Lim SY, Tamura Y, et al
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Our analysis underscores the critical need for parameter optimization (frequency, intensity, duration) to balance oncogenic risks against therapeutic precision
