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(PubMed) Gao L, Mao Q, Cao J, Wang Y, Zhou X, Fan L

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Acetyl glutathione penetrates the mitochondrial membranes, helping to maintain their integrity and function, and crosses the blood-brain barrier, allowing it to directly detoxify and protect the brain

SSRIs have been shown in preclinical models to modulate the hypothalamic-pituitary-adrenal (HPA) axis stress response and reduce systemic inflammation, while paroxetine has the unique added benefit of lowering intestinal inflammation by restoring butyrate-producing bacteria and barrier markers like Muc2 (Luo et al., 2025