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Intraperitoneal or hyperthermic intraperitoneal chemotherapy offers pharmacokinetic advantages in selected fit patients [49,50,51], while bevacizumab-based anti-angiogenic therapy and maintenance poly-(ADP-ribose)-polymerase inhibition (olaparib, niraparib or rucaparib) have become standard for tumours with homologous-recombination deficiency [52, 53]

Laboratory studies continue to investigate how this peptide may influence cellular communication networks involved in vascular development, inflammatory regulation, and structural tissue recovery