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For example, it has been shown that exceeding the upper limit of selenium intake (400 g/d) can lead to selenotoxicity, but no significant symptoms of toxicity were observed when selenium was ingested in the form of SeNPs (1,600 g/d), and some selenotoxicity symptoms did not occur until even an intake of 3,200 g/d (255)

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In this system, Parkin is crucial for the ubiquitin-mediated degradation of misfolded or damaged proteins and the removal of dysfunctional mitochondria through mitophagy [95]