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R., Falcone, J
Ipamorelin and GHRH produce synergistic GH release when co-administered , with the combined response substantially exceeding the sum of individual responses through complementary Gq/11 and Gs signalling pathway interactions in somatotrophs, identical in mechanism to the GHRH-GHRP-6 and GHRH-GHRP-2 synergy documented for non-selective GH secretagogues but without prolactin and cortisol co-stimulation confounding the combined endocrine response
However, achieving meaningful systemic levels via oral delivery is very challenging
Still, they are relevant when the controlled safety evidence is sparse
The injectable versus oral comparison provides additional context on delivery method selection
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