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Practical considerations for combined therapy include: Both medications should be initiated and titrated separately, not simultaneously Metformin is typically started first, with Saxenda added once metformin is established Regular monitoring of weight, metabolic parameters, and PCOS symptoms is essential The combination represents off-label prescribing and requires careful clinical justification Patients considering this combination should have a thorough discussion with their healthcare provider about the potential benefits, risks, costs, and alternatives

You've explored diet changes, exercise routines, and maybe even considered more drastic measures

Henderson CJ, Smith AG, Ure J, Brown K, Bacon EJ and Wolf CR

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