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The medication may look, smell, and feel normal while delivering significantly reduced efficacy

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What is happening physiologically: Two weeks of consistent DSIP dosing has established ongoing modulation of the HPA axis and circadian regulatory systems

Mounjaro belongs to the class of medications called dual GIP/GLP-1 receptor agonists (glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonists)

REDEFINE 2: Efficacy in Type 2 Diabetes REDEFINE 2, announced in March 2025, addressed a distinct population: 1,206 adults with obesity or overweight and type 2 diabetes across 12 countries, randomised in a 3:1 ratio to CagriSema or placebo for 68 weeks