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Different stress conditions, including energy depletion, oxidative stress, and hyperosmolarity which emerge in many diseases and some genetic disorders, lead to shortening the erythrocyte lifespan thus facilitating the removal of the damaged and defective erythrocytes [134]

You didn't stop

It has a solid stress-protective effect and reduces metabolic and functional problems caused by stress in both human and animal organisms exposed to different stress types

Competency to study and learn in stressful contexts: fundamentals of the e-Coping with Academic Stress utility

Therefore, considering significance of both NO-system and egr-1 gene-systems for inflammatory bowel disease (54) as well as for multiple sclerosis (55-57), these may be important also when confronted with severe complications of advanced and poorly controlled IBD as well as multiple sclerosis