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Liraglutide treatment reduced the population of activated microglia by 50% in APP/PS1 mice [73]

The pharmacovigilance data tells a more nuanced story

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For instance, a high acetyl-CoA/CoA ratio in the mitochondrial matrix inhibits pyruvate dehydrogenase (PDH) that catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA (Pietrocola et al., 2015)