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In a clinical trial, pure genistein supplementation (54 mg/day, P.O for one year) improved both cardiac function and left atrial remodeling in postmenopausal women with metabolic syndrome [138]

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This connection is ascribed to either the secondary consequences of obesity or the direct pathophysiological influence of insulin resistance in NAFLD [83]

TB-500, a synthetic analogue of thymosin beta-4, is a 43-amino acid peptide that was first characterized in the 1960s from bovine thymus tissue and has since been studied for its regenerative effects in wound healing and tissue remodeling

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