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Another study that set out to evaluate DNA damage in the ovaries of women with PCOS concluded that there may be significantly less glutathione in the ovary as a result of the condition

While some minor side effects like a bit of temporary soreness around the injection site can happen, its not very common

238 Another uncontrolled study found 15 idiopathic male infertility patients with low sperm concentrations and normal testosterone-to-estrogen ratio had increased sperm concentrations after four months of treatment with letrozole

Published animal research predominantly uses once-daily dosing, though some acute-phase protocols use twice-daily administration

Nucleic Acids Res (2015) 43(1):37384