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The search strategy incorporated the following Boolean logic

[DOI] [PMC free article] [PubMed] [Google Scholar] 96.Leonard G.D., Fojo T., Bates S.E

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Emerging clinical data from retatrutide and survodutide suggest that this strategy may be viable, though long-term safety, durability, and comparative effectiveness remain under active investigation

6.3 Impact on myokine and adipokine signaling in the musclevascular network Beyond mere direct metabolic implications, this integrative framework modulates the signaling pathways of myokines and adipokines, thereby reinforcing the endocrine aspect of the interactions between muscle and vascular systems