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H 2 O 2 has a longer half-life and can cross membranes (Sies, 2014), which confers properties to H 2 O 2 as a mitochondrial signal (Raimundo, 2014)

They work differently

The body appears to recalibrate its cardiovascular response over time, potentially through downregulation of glucagon receptor sensitivity in cardiac tissue or compensatory autonomic adjustments