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Clinical Features Polyuria, polydipsia, polyphagia, and weight loss Nausea, vomiting, abdominal pain Dry mouth, sunken eyes, tachycardia, hypotension, Deep, rapid breathing (Kussmaul respiration) to compensate for acidosis Characteristic fruity (acetone) odor on breath Drowsiness, confusion, and in severe cases, coma E

All of the studies used both in vivo and some form of in vitro methods of data collection in order to observe different treatment effects, allowing for biomechanical, functional (use of AFI index and load to failure), macroscopic and microscopic histological analysis

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