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40 Integration of Molecular and Experimental Studies Future research should focus on integrative approaches that incorporating in silico, in vitro and in vivo techniques

Podocytes are new cellular targets of haemoglobin-mediated renal damage

A pivotal RCT in 116 cannabis-dependent adolescents found that NAC (1,200 mg twice daily) more than doubled the odds of a negative urine cannabinoid test compared to placebo (OR 2.4, 95% CI 1.1-5.2) (Gray et al., Am J Psychiatry, 2012) [76]

We and others have shown in clinical trials that NAC supplement displays pleiotropic effects against inflammation, vasomotor symptom, and formation of dense red blood cells 14,15

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