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Ethics declarations Conflicts of interest JP has received consulting fees from Kyowa Kirin, Eli Lilly, and Theramex

Recently, in an experimental model of obesity induced by sucrose diet, we observed that glycine supplemented to the diet of sucrose-fed (SF) rats decreases the levels of oxidative stress markers and increases glutathione levels in vascular tissue [12]

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He and colleagues point to some of these differences

Despite these developments, significant obstacles remain, including tumor heterogeneity, complex resistance mechanisms, off-target effects, and limited predictive biomarkers