Their involvement spans diverse pathophysiological processes including immune regulation and tissue injury [21, 22]
Wilkinson [email protected] This article was submitted to Clinical and Translational Physiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
In the face of genotoxic stress, p53 directs a metabolic shift that reduces glutamine consumption, thus promoting the conservation of cellular resources and redirecting metabolic intermediates toward pathways essential for cellular survival [33]
This process reduces the level of FFA in the blood, alleviates the metabolic burden on the liver and pancreas, and forms a virtuous cycle of "energy utilization efficiency improvement"
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