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It has been recently shown that efflux pumps in the plasma membrane of cancer cells are crucial for the extracellular efflux of anticancer drugs 134

On one hand, since the activity of the OTC is decreased, it increases the pool of carbamyl phosphate available for this enzyme

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This epigenetic derepression allows senescence-promoting gene expression to increase even when SIRT1 and FOXO3 protein activity is nominally intact a mechanism by which methylation cycle impairment undermines the longevity gene regulatory program from the chromatin level