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Desymmetrization of cyclohexanes by site- and stereoselective CH functionalization

Reported side effects are rare and typically mild: mild redness or irritation at the application site (usually resolves with continued use or concentration adjustment), occasional skin tingling at higher concentrations (typically benign), and temporary dryness during initial use

This increases the time of drug presence in the targeted volume and could prevent bleeding from well-vascularized structures (31)

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It upregulates key glycolytic enzymes (HK2, PKM2) and vascular endothelial growth factor (VEGF), promoting vascular remodeling and alveolar space enlargement, while inhibiting the proliferation and repair of alveolar epithelial cells ( 4.3 Small airway disease Small airway disease, however, serves as the primary pathological driver of airflow limitation in COPD