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These medications are not really meant for the short term, he says
One study on women looking at colon cancer risk found that women with a high polygenic risk score for colon cancer had a significant reduction in risk of CRC with menopausal HRT.[ref] Another study showed that several genetic variants statistically impacted the risk of breast cancer with HRT, but it concluded that more studies are needed
Even though it's
Phase 2 results (48 weeks): 1mg dose: 8.7% average weight loss 4mg dose: 17.1% average weight loss 8mg dose: 22.8% average weight loss 12mg dose: 24.2% average weight loss Placebo: 2.1% average weight loss These numbers came from a 48-week study period, six months shorter than the 72-week SURMOUNT trials
This mitochondrial connection is particularly relevant for lupus, where mitochondrial dysfunction in immune cells has been documented, and for fibromyalgia and chronic fatigue that frequently accompany autoimmune conditions
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