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P.LinS.HouC

In a randomized, double-blind, placebo-controlled trial, once-weekly exenatide (2 mg) administered for 48 weeks significantly improved motor scores in patients with PD, with benefits sustained even after treatment discontinuation ( Collectively, these findings indicate that incretin mimetics provide neuroprotection extending beyond metabolic regulation by targeting multiple pathogenic processes in PD, including mitochondrial dysfunction, neuroinflammation from oxidative stress, sirtuin dysregulation, insulin resistance, and S toxicity (Figure 2)

Hence, users may trade overweight for more rapid progression toward weakness and frailty

Fundament Clin Pharmacol

Another study showed that fluoxetine treatment in ewes during the last month of pregnancy reduced placental nodule growth, shortened the gestational period by 4.5 days, and decreased the birth weight of lambs following exposure in utero