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In this hypothesis, neglecting the mass creation at the interface and all border effects, integrating equations (6) and (7) on a surface immersed in the lesion and taking nutrients at equilibrium give us: This equation can be solved by an exponential law, whose decreasing time constant is = 1/

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doi: 10.1016/j.cmet.2006.01.004 5 BestermanHSBloomSRSarsonDLBlackburnAMJohnstonDIPatelHRet al