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Pore-forming proteins as drivers of membrane permeabilization in cell death pathways

Glatter wasnt involved in the study

When compared to the other analogs in the study, the one that showed the best activity has a 3hydroxy group next to the 4carboxyl, which may have influenced the increase in potency, when compared to the other compounds in the study which were more than 27 times less potent (when compared to the second most potent in the study, the others being even less potent)

The evidence therefore supports an individualised approach rather than a universal recommendation