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In a large observational study, 67,731 participants, who had no evidence of dementia, were non-diabetic, and aged 65 were followed from January 2004 to December 2009, to observe the onset of T2DM and compare the risk of the incidence of dementia associated with the use of anti-diabetic drugs and reported that metformin reduced the risk of developing dementia (256)

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Supplementation, particularly in a liposomal format, helps bridge this gap by ensuring higher cellular uptake