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Although PD can be inherited, it is more likely a sporadic disease because fewer than 10% of PD cases have an indisputable family history (Thomas and Beal, 2007)

454 Moreover, centrally mediated factors, such as cognitive processes (e.g., attention, distraction, catastrophizing), contextual beliefs about pain, and emotional states (e.g., depression, anxiety), significantly influence the pain experience

[DOI] [PubMed] [Google Scholar] 77.King S.J., Isaacs A.M., OFarrell E., Abizaid A

Among the secondary prevention population ( n =95,247 at baseline), widespread SGLT2i use was projected to prevent 5402 non-fatal MIs, 66,490 HF hospitalisations, 2324 ESKD events and 7000 deaths, but increase the number of non-fatal strokes by 996