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16 Due to its oxygen rich and PUFA rich environment, the lung is particularly susceptible to oxidative injury, especially when mechanical ventilation with high partial pressures of O 2 is necessary, and normal physiological antioxidant defenses are depleted and are unable to scavenge free radicals or metabolize downstream reactive oxygen species (ROS)

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Asymptomatic gallstones generally allow continued tirzepatide use with monitoring, while symptomatic gallstones require gastroenterology referral and clinical judgment about temporarily holding the medication