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Together, our data reveal correlations between different cell types and ferroptosis at the single-cell level, and identify factors that may affect the sensitivity of dopaminergic neurons to ferroptosis
The key pathophysiological downstream effect of GBA mutations is decreased glucocerebrosidase (GCase) activity and lysosomal dysfunction and experimental studies have shown a reciprocal relationship of GCase activity and -synuclein aggregation [191, 192]
Struggle with obesity or overweight conditions
BSO had merely no effect on [-Glu-Glu] e , while SFN enhanced it, although not significantly (135 25%, n = 3)
No new safety signals emerged, and it appears to share the classs risk-benefit profile
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