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The mild OS may activate the bladder afferent nerves (188) and stimulate the detrusor muscle cells directly (195), leading to bladder hyperactivity, while severe or prolonged OS can induce detrimental alterations in nerves and the detrusor muscle ultimately resulting in detrusor underactivity (196)

To view or add a comment, sign in Shivani Garg, MD, PhD, an assistant professor of medicine and medical director of the Lupus and Lupus Nephritis Clinics at the School of Medicine and Public Health, University of Wisconsin-Madison, presented the findings of an observational study that confirmed and extended the results from an earlier study carried out by her research group that the ideal blood hydroxychloroquine level lay somewhere between a lower limit of 750 ng/mL and an upper limit of 1150 ng/mL(65% eliminated by kidneys) for most patients with SLE