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As evidence of this, at the chosen doses, the combination therapy did not induce GLP-1-associated vomiting or GI distress in the animals, despite causing greater weight loss than semaglutide alone

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Clinical trials indicate bethanechol is no more effective than placebo, and its use is associated with significant dose-dependent unpleasant side effects including blurred vision, bradycardia, bronchospasm, and GI upset (Barrett 1981