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In addition, the recovery of E GSH [IMS] after oxidant treatment is strongly impaired in glr1 cells compared to wt cells (Figure 3C)

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The first is a dimer (consists of two units), whereas the others are tetramers (four subunits)

Astrogliosis is prevalent in the epilepsies, and interestingly a mouse forebrain neuron-specific knockout of SOD2 resulted in seizures, oxidative stress, and marked GFAP and vimentin gene upregulation, indicative of astrogliosis resulting from increased neuronal mtROS (Fulton et al., 2021)

10.1016/j.biopha.2022.113953 13 ChenJ.ShiZ.ZhangC.XiongK.ZhaoW.WangY