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Discussion Using a vitamin B 12 deficiency phenotype definition, consistent with previous reports [1, 2], there were 487 (6.8%) deficient individuals of White European ancestry receiving metformin in the UKB cohort out of a total of 7173

Therefore, there is a very low risk of B12 toxicity, even at high doses like 1,000 mcg a day

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They work together to supply your nerves with energy, keep them functioning smoothly, and help to repair nerve fibers and restore nerve function