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Exendin-4 induces a novel extended effect of ischemic tolerance via crosstalk with IGF-1R

Animals were excluded from the behavioral dataset if the ASR in response to a 107-dB SPL stimulus in quiet was less than 3 standard deviations above the average baseline activity recorded prior to the startle stimulus

Moreover, in lipopolysaccharide (LPS)-treated mice or primary microglial cultures, increasing NADH levels reversed the protective effects of glycolytic inhibition, driving NF-B-mediated proinflammatory gene expression (IL1, IL6, and iNOS) through dimerization of the NAD(H)-sensitive transcriptional corepressor CtBP [66]

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