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Moreover, rendering these ALS mice germ-free or treating them with antibiotics significantly accelerated their motor neuron degeneration, implying that some aspect of the microbiome is beneficial in ALS [83]

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Interestingly, the sleep-wake cycle does appear to align with chronotypes, as traditional Night Owls who naturally go to bed much later (2 am to 3 am) may be less affected by late night snacking than Early Birds