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Pak J Med Sci 29 , 13381343 (2013)

S.BanerjeeR.MohanakumarK

As GPX4 serves as the master regulator of lipid hydroperoxide reduction, its suppression triggers irreversible lipid peroxide accumulation that culminates in ferroptotic cell death (67, 68)

Deficiency of GPx results in direct tissue damage and activation of age-related NF-B inflammatory pathways [57]

In this way, vitamin C acts less like a single antioxidant and more like a support molecule that helps maintain the bodys entire antioxidant defense system