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Evidence on B12 Supplementation During GLP-1 Therapy Clinical trials of semaglutide for weight loss (the STEP trials with over 4,500 participants) did not routinely pair semaglutide with B12 injections or measure specific B12 supplementation outcomes
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If your baseline B12 is already adequate, MIC B12 injections target metabolic support rather than deficiency correction, making proper storage even more critical for consistent benefit
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PubMed reference (NNMT inhibition & metabolic health)
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