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These enzymes are rate-limiting in the production of ceramides, which constitute approximately fifty percent of the intercellular lipid matrix and are absolutely essential for maintaining barrier impermeability

Altogether, these data suggest that the ability of AML cells to prevent lipid peroxides accumulation by increasing their cystine uptake to support GSH after exposure to APR-246 is a key determinant of the sensitivity to this compound

doi:10.4081/aiua.2015.3.190

[164] Quercetin has been shown in vitro to increase the concentration of doxorubicin in multidrug-resistant human breast cancer cells