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Decreased -cell proliferative capacity is also age-dependent in rodents and humans [526,[531], [532], [533], [534], [535], [536], [537]]

[6] If it is given by injection into a vein without making it approximately isotonic, breakdown of red blood cells may occur

These trials included both single-dose pharmacokinetic studies and long-term efficacy trials extending up to 24 weeks of continuous administration

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