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Patch formulations, by contrast, have struggled to demonstrate equivalent weight loss in published trials, with some showing only 812% reduction compared to placebo
Systemic effects that have been reported in trials, or that are mechanistically expected from elevated GH and IGF-1, include: Water retention and mild edema , particularly in the hands, ankles, and face Tingling, numbness, or 'pins and needles' (paresthesia) , sometimes linked to fluid pressure on nerves Headache and facial flushing , often shortly after administration Joint aches or stiffness (arthralgia) Transient changes in blood glucose due to GH's counter-regulatory effect on insulin Fatigue, dizziness, or a feeling of light-headedness in some individuals It is important to be candid about the limits of this evidence
A: Expect initial improvements in texture and radiance within 24 weeks
However, the weight loss seen in this study of people with type 2 diabetes is broadly comparable with that previously observed with injectable GLP-1
