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Quick Answer: Tirzepatide begins lowering blood sugar within 1-2 weeks, with peak A1C reductions at 20-24 weeks, while initial weight loss typically starts within 2-4 weeks, with maximum effects occurring between 36-72 weeks

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In contrast, oral Wegovy must be taken on an empty stomach with no more than 4 ounces of water, and individuals must wait at least 30 minutes before eating, drinking, or taking other medications

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