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Hepatology 4 , 15601599 (2018)

Although the molecular mechanisms of SNAC enhancement of intestinal permeability are not fully understood, 29 the use of SNAC to increase oral bioavailability of several peptide hormones has been proven, including salmon calcitonin, parathyroid hormone, GLP-1RA, and peptide YY

The increased permeability persisted for 4 to 6 weeks as measured by dynamic contrast-enhanced MRI and by tracking serum levels of a brain-specific factor (Table 1) 119

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Semax is a cognitive and neurological peptide, closer in function to NAD+ than to GHK-Cu