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The clinical pictures of vitamin B12 allergy caused by type 1 hypersensitivity that have been revealed with basophile histamine release test and skin prick tests as we have performed in our patient.10 We did not perform basophile histamine release test or specific IgE determination to indicate type 1 hypersensitivity reaction because of positive SPT results of both types of cobalamin preparation

One polymorphism, a single-nucleotide polymorphism producing a single-residue substitution in the amino-terminal extracellular domain (A118G), has been studied in some detail and shown to specifically affect receptor activation by -endorphin relative to enkephalin (Bond et al., 1998)

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2g/day for those who drink alcohol)

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