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Here we report that these two oncogenic pathways may not act in concert, but act apparently partially antagonistic at least in human GIC models, potentially accounting for disappointing results with inhibition of either pathway in the clinic 29,30,31 , but also providing new concepts on how to modulate these pathways more efficiently to improve the outcome of glioblastoma

The introduction of these pharmacological interventions represents a paradigm shift, acknowledging the biological factors that contribute to obesity and making safe, effective weight loss more attainable

Both remain unapproved for this use, so better depends on context

It is not typically fatal

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