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doi: 10.1038/nm1168 65 ElsonAETDotsonCDEganJMMungerSD

The only scenario where a slightly faster escalation might be considered is for someone transitioning from high-dose tirzepatide (10 to 15 mg) who shows zero GI response at 1 mg and 2 mg

After a mean follow-up of 49.5 months, the oral semaglutide group 12% of participants suffered major adverse cardiovascular events compared with 13.8% in the standard care group (a significant 14% reduction)