GLP1-induced nausea is mediated in the hindbrain (area postrema)
Protective effect of a Glp-1 analog on ischemia-reperfusion induced blood-retinal barrier breakdown and inflammation
And to those people, I want to say its not your fault. The special also brought together for the first time two major competitors that are expanding the pharmaceutical weight loss drugs conversation: Negelle Morris, senior vice president, cardiometabolic sales of Novo Nordisk Inc., the Danish company behind Ozempic and Wegovy, and Rhonda Pacheco, group vice president of diabetes and obesity for Eli Lilly, the American pharma company that manufactures and sells Mounjaro and Zepbound
The rationale for combining them is mechanistic complementarity (different signaling pathways, both implicated in tissue repair) and clinical anecdote in the peptide-therapy community not formal head-to-head or combination-vs-monotherapy data
During the reproductive years when E2 levels are high, phytoestrogens may compete with E2 for receptor sites and thereby have an anti-estrogenic effect, whereas in menopause, when E2 levels are low, phytoestrogens may have a pro-estrogenic effects through their ability to stimulate estrogen receptors (to a lesser degree than endogenous estrogens)
