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The first involves binding with the Toll-Like Receptors (TLR) complex, which activates nuclear factor B and leads to the production of pro-inflammatory cytokines, including IL-1 and TNF-, as well as reactive oxygen species (ROS) and reactive nitrogen species (RNS)

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Under the Therapeutic Goods Act 1989 , peptide products are regulated as therapeutic goods in Australia

Savage-Dunn C, Yu L, Gill K, Awan M, Fernando T (2011) Non-stringent tissue-source requirements for BMP ligand expression in regulation of body size in Caenorhabditis elegans