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Sirtuin-1 can promote Nrf2 deacetylation and enhance its transcriptional activity, further protecting against mitochondrial oxidative stress (Xu et al., 2021)

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This assessment is even more relevant if it is considered that the oxidized state would lead to an intramolecular disulfide bond, which usually could not lead to a single reduced Cys residue under reducing conditions, but must allow two bonds with mPEG-MAL, unless the second Cys residue is structurally or spatially hidden

The benefit of this is that this higher dose can be injected in one shot and the benefits of B12 supplementation may be felt sooner

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