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MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a naturally occurring peptide encoded within mitochondrial DNA the powerhouses of your cells

D., & Panda, S

G., Zupec-kania, B

Although there was no difference in the severity of hepatic encephalopathy between the two groups, NAC-treated patients had a higher incidence of signs of raised intracranial pressure (dilated pupils and seizure activity) and required more measures to decrease intracranial pressure (use of mannitol, hyperventilation, and cooling blankets) compared to patients in the control group

However, most of the harms were mild and could decrease over the duration of treatment, the researchers pointed out