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Other possible mechanisms to improve insulin sensitivity in NAFLD reported in the literature include the regulation of the acetyl-CoA/CoA ratio in mitochondria, modulation of the pyruvate dehydrogenase complex (PDHC) activity, altering the expression of glycolytic and gluconeogenic enzymes as well as the expression of genes associated with the insulin signaling cascade, and stimulation of the insulin-like growth factor-1 (IGF-1) axis and IGF-1 signaling cascade (57)

Supporting barrier integrity and improves microcirculation

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Rege, J

All mice were housed under a 12 h light/dark cycle, with the temperature consistently maintained between 18 C and 23 C and the humidity kept at ~50%