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Vet Res Commun 41 , 4956, (2017)

On top of the role of NAD + as a direct substrate for the TCA and ETC, much of the influence of NAD + on mitochondrial homeostasis is through the NAD + -consuming enzymes sirtuins

These kinases include Jun N-terminal kinase (JNK), inhibitor of nuclear factor kappa B kinase beta (IKK), and suppressor of cytokine signaling-3 (SOCS-3)

224,233 Benfotiamine, a lipid-soluble thiamine derivative, has been shown to activate transketolase activity, thereby redirecting glycolytic intermediates away from the hexosamine pathway